Oxycodone is one of the most powerful medications for pain control that can be taken orally. When combined with other ingredients, it is marketed as Oxycontin, Percodan, Endodan, Roxiprin, Percocet, Endocet, Roxicet, Tylox, Combunox, Endone, OxyIR, OxyNorm, Percolone, OxyFAST, and Roxicodone.


Oxycodone is a potent and addictive opioid analgesic medication synthesized from thebaine. Its name is derived from codeine - the chemical structures are very similar, differing only in that the hydrogen on the codeine is oxidised to a hydroxyl group, hence 'oxy' and the hydroxyl group from the codeine becomes a ketone group, hence 'oxycodone.'

It is effective orally and is marketed in combination with acetylsalicylic acid (Percodan, Endodan, Roxiprin) or paracetamol (Percocet, Endocet, Roxicet, Tylox) for the relief of pain. More recently, ibuprofen has been added to oxycodone (Combunox). It is also sold in a sustained-release form by Purdue Pharma under the trade name OxyContin as well as generic equivalents, and instant-release forms Endone, OxyIR, OxyNorm, Percolone, OxyFAST, and Roxicodone.

In the United States, oxycodone is a Schedule II controlled substance both as a single agent and in combination products containing paracetamol, ibuprofen or aspirin.