The known active constituent of Salvia divinorum is a trans-neoclerodane diterpenoid known as Salvinorin A.
Salvia divinorum, also known as Diviner’s Sage, ska María Pastora, Sage of the Seers, or simply by the genus name, Salvia, is a
psychoactive herb which can induce strong dissociative effects. It is a member of the sage genus and the Lamiaceae (mint) family. The Latin name Salvia
divinorum literally translates to "sage of the seers".
Salvia divinorum has a long and continuing tradition of use as an entheogen by indigenous Mazatec shamans, who use it to facilitate visionary states of consciousness during spiritual healing sessions. The plant is found in isolated, shaded, and moist plots in Oaxaca, Mexico. It grows to well over a meter in height. It has hollow square stems, large green leaves, and occasional white and purple flowers. It is thought to be a cultigen. Its primary psychoactive constituent is a diterpenoid known as salvinorin A, which is a potent ?-opioid receptor agonist. Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state this way. Salvia divinorum can be chewed, smoked, or taken as a tincture to produce experiences ranging from uncontrollable laughter to much more intense and profoundly altered states. The duration of effects is much shorter than that of other, more well-known psychedelics; the effects of smoked salvia typically last for only a few minutes. The most commonly reported after-effects include an increased feeling of insight, an improved mood, a sense of calmness, and an increased sense of connection with nature.